Archive for June 2007

Jun212007

Life is so unpredictable..

Fiona
2

Life was so fragile yet so priceless. I have an co-worker who just found passed away yesterday, we all was so shock about it, and he already passed for 2 day only we noticed it! Caused at first he said he maybe will going back to his hometown so no one suspect anything, as you know most of my colleague work as motorcycle foremen always also so dirty so their room has those rat corpse smell is nothing to surprised about. So yesterday after around 5pm
1 of my malay colleague walk up to my mom and seriously said wanna tell her something, at first we thought he was just wanna play another trick on us like he always do, then he suddenly blurt out that “he’s” dead! We all just gasped.When we found him, he was lying on the bed his hand holding his chest with his back facing up, like a crouching in pain position, for now we guessed maybe he has some kind of heart illness and wanna take his medicine but too late. His body was already swell and already has a strong corpses odour..He ages 39 haven’t married, becaused of a accident he kinda has some mental problem but still a kind guy, he’s parents has passed away already just left his elder bro who ill treated him! 2 sis who loved him dearly! Thats his family prob le, can’t said much. Just 2 day’s ago still seeing him work and still look fine and i still praising him for having a nice haircut,can’t believe monday night was the last time i ever see him again sigh..All i hope is he’ll rest in peace now and be in a peaceful place. So we should always cherished everything around us and also everyone around us..Be happy always

Posted in Uncategorized

Jun62007

Love is everything we need..

Fiona
1

Recently too many unhappy stuff happen to me, making me feel the world no one cared about me, i felt i have changes too, last time, i don’t mind if i treating someone good and have nothing in return, i just wish my friend’s to be happy thats enough.. No i not that noble, but i just felt if someone sad i can lend a pair of ear to listen is my pleasure, i still do now,but i hope i’ll get it in return.All the unhappy stuff just make me thing my life’s sucks.. But recently my friend who i just know, show me that life’s not that sucks after all. He just my cyber friend, but he make me feel his sincerity, he make me remember my belief, my faith i once have but have been hid under all the sadness i have been thru recently, he’s words is just like a sun shining thru the cloudy sky. He always said ” Love is the most strongest energy,” ask me to ” Start my day with love, lived and fill my day with love and end it with love too” He told me love doesn’t just meant for couple, it can means among family & friends, all i have to do is treat people and myself sincerely..I wanna try doing it that way. Caused love is better then hatred, Whatever is passed has passed. I hope i can live every single day with a smile and end with a smile too. But of caused le, when i sad i still will be moody and cry, but i hope after all the tears has dry i will changes to be the cheerful girl again (^_^)

Free Graphics - MySpace/Xanga/Friendster

Posted in Be happy alwayss...

Jun32007

Time flies.. Ms annoyingangelz is 1 years old!!

Fiona
2

Yup yup!! I have successfully post blog for 1 year already!! I just realised it while browsing thru my blog. Wow 1 year many things does happen, this blog has many silly thought, happy and unhappy stuff as well as some junk post :P Hmm

Thanks to all my blog reader (Pss do i have one ??) my friends and myself for supporting my blog!! Hahaha now is mom birthday eve, means few more minute i gonna wished her Happy Birthday!! Yoohooo.. Whatever unhappiness must be over already la.. Anyway thanks for reading Ms Annoyingangelz and accompany her to past 1 year.. More post to come!! hehe…Nice song for everyone!!

A little faith brightens a rainy day
Life is difficult you can’t go away
Don’t hide yourself in the corner
You have my place to stay
Sorrow is gonna say goodbye
Opens up You’ll see the happy sunshine
Keep going on with your dream
Chasing tomorrow’s sunrise
The spirit can never die
Sun will shine, my friend
Won’t let you cry, my dear
Seeing you shed a tear,
Make my world disappear
You’ll never be alone in darkness
See my smile, my friend
We are with you, holding hands
You have got to believe
You are my destiny
We’re meant to be your friends
That’s what a friendship be

Posted in Uncategorized

Jun22007

Review on my last post.

Fiona
2

Well at last i know my illness full name and also starting to learn more about it. The first time i post my blister and bullous post huh? firstly i wanna let my blog reader and friends to know more about me. Recently i have many unhappy stuff happens to me, making me realise that i really don’t have much friend after all, so now i won’t force myself to make friends or please anyone. I’ll try to changes my bad attitude, at the same time focus on whats really important. My family, my illness , my study , my work and most important of all myself!! I do hope that luck will befall on me and let someone out there who can really saved me and tell me there’s a cured for this illness, whose name is kinda long”Epidermolytic hyperkeratosis (Bullous Ichthyosis)

Posted in Uncategorized

Jun22007

Epidermolytic hyperkeratosis.bullous congenital ichthyosiform erythroderma,

Fiona
0

Epidermolytic hyperkeratosis, also called bullous congenital ichthyosiform erythroderma, is a rare autosomal dominant ichthyosis and presents at birth or shortly thereafter as erythema, blistering and/or peeling.
A better understanding of the mutations in keratin production and the molecular mechanisms that cause structural instability in keratinocytes, leading to easy blistering, hyperproliferation and hyperkeratosis, may be the key to finding therapeutic strategies based on gene therapy and may open doors to possible options for a permanent corrective therapy for epidermolytic hyperkeratosis.
Dr. RoopJiang Chen M.D., a post-doctoral fellow in the laboratory of Dennis Roop, Ph.D., in the Center for Cutaneous Molecular Biology at Baylor College of Medicine’s departments of molecular and cellular biology and dermatology in Houston, discusses his and his laboratory’s research on development of gene therapy for epidermolytic hyperkeratosis and what may lie in store for the future concerning the possible treatment therapies of this skin disease.
A review
In the United States and worldwide, epidermolytic hyperkeratosis is a life-long condition without a gender or race predilection, and affects one in 200,000 to 300,000 persons.
Morbidity includes recurrent infection, sepsis and electrolyte imbalance, which are possible during the neonatal period, and mortality is possible if the sepsis and electrolyte imbalance are not treated properly. The differential diagnoses for epidermolytic hyperkeratosis include epidermolysis bullosa, lamellar and X-linked ichthyoses and staphylococcal scalded skin syndrome (SSSS) as well as Stevens-Johnson syndrome and toxic epidermal necrolysis.
A definitive diagnosis, however, is of paramount importance. This can be achieved through keratin gene defect studies, clinical presentation and careful history-taking, biopsies (diagnostic in de novo cases) and prenatal diagnosis made through analysis of chorionic villus sampling, amniotic cells and fetal skin biopsies. Histologic studies are distinctive but not unique.
According to Dr. Chen, the current treatment modalities are limited to relieving the symptoms of this dominant monogenetic disease. Woundcare for the blistering and aggressive moisturization/emollients are important. Some improvement has been noted with high-dose beta-carotene, systemic retinoids, topical retinoids, 10 percent glycerine, lactic acid, alpha hydroxy acid, calcipotriol, antibacterial soap and urea. However, in the long term, understanding and addressing the origin of this skin disease — down to its genetic mutation — will prove more beneficial to patients and physicians, as well as to healthcare systems worldwide.
Of mice and men
Dr. Chen tells Dermatology Times, “Epidermolytic hyperkeratosis is caused by mutations in either the keratin K1 or K10 genes.
“These mutations lead to defective suprabasal keratinocytes, resulting in blisters and hyperkeratosis. Gene therapy may be the answer in successfully treating this ichthyosis at the molecular level. Our laboratory previously developed an inducible mouse model for epidermolysis hyperkeratosis which is viable, due to the fact that the expression of a mutant K10 allele can be restricted to a focal area of the skin.
“Once the mutant K10 allele is activated in epidermal stem cells by topical application of an inducer, these stem cells continuously give rise to defective progeny that form hyperkeratotic lesions which persist for the life of the mouse. This mouse model also revealed that partial suppression of the mutant K10 allele may be sufficient to eliminate the clinical phenotype.”
To test this novel therapeutic strategy, Dr. Chen and his team of researchers developed siRNAs that specifically target mutant K10 transcripts for degradation, without affecting wild type K10 transcripts. He introduced these siRNAs into lentiviral vectors, and subsequently used them to transduce cells expressing both wild type and mutant K10 constructs.
Dr. Chen observed that under these conditions, an efficient knock-down of mutant, but not wild type, K10 transcripts could be achieved. He claims that these results may prove to be a very vital step forward in forging a novel gene therapy and possible permanent corrective therapy for this debilitating skin disease. Dr. Chen and colleagues at the Center for Cutaneous Molecular Biology are currently using this lentiviral vector to transduce keratinocytes isolated from his epidermolytic hyperkeratosis mouse model. They also are testing whether the correction of the epidermolytic hyperkeratosis phenotype can be achieved in vivo when these cells are introduced into a graft on nude mice.

Posted in Health & Body